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Related Experiment Videos

Decrease of caffeine elimination in man during co-administration of 4-quinolones.

W Stille1, S Harder, S Mieke

  • 1Zentrum der Inneren Medizin, Infektiologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Federal Republic of Germany.

The Journal of Antimicrobial Chemotherapy
|November 1, 1987
PubMed
Summary
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Fluoroquinolone antibiotics like enoxacin and ciprofloxacin significantly impact caffeine metabolism. Enoxacin markedly prolonged caffeine

Area of Science:

  • Pharmacology
  • Drug Metabolism
  • Clinical Pharmacy

Background:

  • Caffeine is a widely consumed stimulant.
  • Fluoroquinolones are broad-spectrum antibiotics.
  • Drug-drug interactions can alter pharmacokinetic profiles.

Purpose of the Study:

  • To investigate the pharmacokinetic interactions between caffeine and fluoroquinolone antibiotics.
  • To assess the impact of ofloxacin, ciprofloxacin, and enoxacin on caffeine elimination.

Main Methods:

  • Single-dose pharmacokinetics of caffeine (220-230 mg) were evaluated in 12 healthy males.
  • Volunteers received caffeine before and during treatment with ofloxacin (200 mg bd), ciprofloxacin (250 mg bd), or enoxacin (400 mg bd).
  • A cross-over study design was employed to compare drug effects intra-individually.

Related Experiment Videos

Main Results:

  • Ofloxacin did not significantly alter caffeine pharmacokinetic parameters (T1/2el, Cmax, Cltot, aVd).
  • Enoxacin significantly prolonged caffeine elimination half-life (T1/2el) by 260%, increased Cmax by 41%, reduced volume of distribution (aVd) by 20%, and decreased total body clearance (Cltot) by 78%.
  • Ciprofloxacin prolonged T1/2el by 15%, decreased aVd by 25%, and decreased Cltot by 33%.

Conclusions:

  • Ciprofloxacin and enoxacin significantly inhibit caffeine elimination.
  • Clinicians should be aware of potential interactions when prescribing these fluoroquinolones to patients consuming caffeine.
  • Further research may explore the mechanisms of inhibition and clinical implications.