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Related Experiment Video

Updated: Oct 12, 2025

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

Microbiota links to neural dynamics supporting threat processing.

Caitlin V Hall^1,2,3, Ben J Harrison⁴, Kartik K Iyer¹

¹Clinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Human Brain Mapping

|November 23, 2021

Summary

This summary is machine-generated.

Gut microbes impact threat responses by altering brain activity in key areas. Specific bacteria, like Ruminococcus, are linked to how the brain processes threats.

Keywords:

anterior insula dorsal anterior cingulate gut-brain axis microbiota neuroimaging threat processing

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Published on: October 27, 2019

Area of Science:

Neuroscience
Microbiology
Psychology

Background:

The gut microbiota's influence on behavior, particularly threat responses, is increasingly recognized.
Neural computations involving the anterior insular cortex (AIC) and dorsal anterior cingulate cortex (dACC) are crucial for threat appraisal.

Purpose of the Study:

To investigate how gut microbial composition affects neural activity within the AIC-dACC circuitry during threat processing.
To explore the extent and mechanisms of this microbiota-brain interaction.

Main Methods:

Utilized a threat processing task combined with neuroimaging (fMRI) in healthy participants.
Employed 16S rRNA sequencing for gut microbiota profiling and computational modeling.

Main Results:

Found significant interactions between gut microbial ecological indices and AIC-dACC neural dynamics during threat processing.
Identified a specific link between the abundance of Ruminococcus bacteria and altered AIC-dACC connectivity and activity during threat updating.

Conclusions:

Gut microbiota composition, particularly Ruminococcus, plays a role in modulating neural circuits involved in threat processing.
Suggests microbiota-derived metabolites as potential mediators for these brain-behavior relationships, warranting further research.