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Related Concept Videos

Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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Local Anesthetics: Adverse Effects01:12

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While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
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Hypersensitivities01:30

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Related Experiment Video

Updated: Oct 12, 2025

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
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Photoallergy to Naproxen.

Patricia Rojas Perez-Ezquerra1, Ines Torrado-Español1, Melina Tejero-Alcalde1

  • 1Allergy, Hospital General Universitario Gregorio Marañon, Madrid, ESP.

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Summary

This study details a photoallergic reaction to naproxen, a type of drug-induced photosensitivity. Photopatch testing confirmed the allergy, highlighting the importance of this diagnostic method for photosensitive reactions.

Keywords:
naproxenpatch testsphoto patch testsphotoallergyphotodematosis

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Area of Science:

  • Dermatology
  • Allergology
  • Pharmacology

Background:

  • Photosensitivity reactions, or photodermatosis, involve skin responses to electromagnetic radiation.
  • Drug-induced photosensitivity presents as either photoallergy or phototoxicity.
  • Photoallergic reactions are immune-mediated, specifically Type IV hypersensitivity.

Observation:

  • A 41-year-old man with no prior allergy history was referred for drug allergy evaluation.
  • Conventional and photopatch tests (UVA irradiation) were conducted with readings at 48, 96, and 24 hours post-irradiation.
  • The patient exhibited a reaction consistent with photoallergy.

Findings:

  • Photopatch testing confirmed a photoallergic reaction to naproxen.
  • Naproxen sensitization was identified as the cause of the patient's photosensitivity.
  • The case illustrates a specific instance of drug-induced photoallergy.

Implications:

  • Photopatch testing is crucial for diagnosing photoallergic drug reactions.
  • Identifying the causative agent, like naproxen, is essential for managing photosensitivity.
  • This case underscores the clinical significance of recognizing and diagnosing drug-induced photosensitivity.