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The Natural Course of Adult-Onset Food Protein-Induced Enterocolitis Syndrome
Jimena Crespo1, María Esperanza Pérez-Pallise2, Filip Skrabski2
1Allergy Department, Clínica Universidad de Navarra, Madrid, Spain; Universidad de Alcalá, Madrid, Spain.
Summary
Adult-onset food protein-induced enterocolitis syndrome (FPIES) can resolve in some adults. This study found that 40% of adult FPIES patients achieved tolerance after a mean of 17.8 months, indicating a potential for outgrowing the condition.
Area of Science:
- Gastroenterology
- Allergy Immunology
Background:
- Adult-onset food protein-induced enterocolitis syndrome (FPIES) is increasingly recognized.
- Adult FPIES presents with distinct dietary triggers and symptoms compared to pediatric FPIES.
- The natural history of FPIES in adults remains poorly understood.
Purpose of the Study:
- To investigate the natural course and long-term outcomes of adult-onset FPIES.
Main Methods:
- An ambispective study was conducted on adults diagnosed with acute FPIES between 2016 and 2021.
- Data collected included demographics, symptoms, food triggers, and oral food challenge (OFC) outcomes.
- Analysis focused on baseline characteristics and follow-up data.
Main Results:
- Forty-two adults (83.3% female, median age 40) were included.
- Diarrhea (92.9%) and abdominal cramps (71.4%) were predominant symptoms, with shellfish and fish as common triggers.
- Six patients (40%) achieved tolerance after a mean of 17.8 months; 57.1% of OFCs were positive.
Conclusions:
- Adult-onset FPIES may resolve in a subset of patients.
- A significant proportion of adult FPIES patients can achieve tolerance over time.
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