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Naltrexone decreases self-injurious behavior.

B H Herman1, M K Hammock, A Arthur-Smith

  • 1Brain Research Center, Children's Hospital National Medical Center, Washington, DC 20010.

Annals of Neurology
|October 1, 1987
PubMed
Summary
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Naltrexone significantly reduced self-injurious behavior (SIB) in adolescents. Dose-dependent decreases in SIB were observed in mentally retarded subjects, suggesting a role for opioid peptides in SIB.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Developmental Psychology

Background:

  • Self-injurious behavior (SIB) is a serious concern in adolescents.
  • The underlying neurobiological mechanisms of SIB are not fully understood.
  • Opioid peptides are implicated in various behavioral regulation processes.

Purpose of the Study:

  • To investigate the efficacy of naltrexone in reducing SIB frequency.
  • To explore dose-dependent effects of naltrexone on SIB.
  • To examine the potential role of opioid peptides in SIB.

Main Methods:

  • Three male adolescents with SIB participated in the study.
  • Naltrexone was administered at varying doses (0.5, 1.0, 1.5, and 2.0 mg/kg).
  • The frequency of SIB was systematically recorded and analyzed.

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Main Results:

  • Naltrexone administration led to a significant reduction in total SIB frequency across all subjects.
  • Two subjects with intellectual disabilities exhibited dose-dependent decreases in SIB.
  • The observed effects suggest a correlation between naltrexone dosage and SIB reduction.

Conclusions:

  • Naltrexone demonstrates potential as an effective intervention for reducing SIB in adolescents.
  • Opioid peptide systems may play a significant role in the modulation of SIB.
  • Further research is warranted to elucidate the precise mechanisms and optimize treatment strategies.