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Updated: Oct 12, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Transition-metal catalyzed oxidative spirocyclization of N-aryl alkynamides with methylarenes under microwave
Jin-Wei Yuan1, Chen-Xu Mou1, Yang Zhang1
1School of Chemistry & Chemical Engineering, Henan University of Technology, Zhengzhou 450001, P. R. China. yuanjinweigs@126.com.
Abstract:
A practical synthetic route to construct a variety of 3-benzyl spiro[4,5]trienones was developed via transition-metal Cu/Ag-catalyzed oxidative ipso-annulation of activated alkynes with unactivated toluenes using TBPB as an oxidant under microwave irradiation. This method allows the formation of two carbon-carbon bonds and one carbon-oxygen bond in a single reaction through a sequence of C-H oxidative coupling, ipso-carbocyclization and dearomatization. The advantages of this protocol are its operational simplicity and broad substrate scope, and the ability to afford the desired products in moderate to good yields.
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