Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

288
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
288
Adrenergic Neurons: Neurotransmission01:27

Adrenergic Neurons: Neurotransmission

4.5K
Postganglionic sympathetic fibers (except those supplying the sweat glands) releasing noradrenaline or norepinephrine are called noradrenergic or adrenergic neurons. Noradrenaline, dopamine, adrenaline, or epinephrine are collectively called "catecholamines" as they contain a catechol moiety and an amine side chain. The five stages of neurotransmitter release involve their synthesis, storage, release, reuptake and metabolism.
Synthesis: Catecholamine synthesis requires tyrosine, which...
4.5K
Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

1.2K
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
1.2K
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

275
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
275
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.8K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.8K
Adrenergic Receptors: β Subtype01:26

Adrenergic Receptors: β Subtype

2.7K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond RBD: covert REM sleep abnormalities in Parkinson's disease.

NPJ Parkinson's disease·2026
Same author

Polarizer-assisted pupillometry through closed eyelids, overcoming pupil position dependence.

Journal of biomedical optics·2026
Same author

Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse.

PloS one·2025
Same author

An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening.

Science advances·2025
Same author

Anticipatory eye gaze as a marker of memory.

Communications psychology·2025
Same author

Abrupt and Gradual Changes in Neuronal Processing upon Falling Asleep and Awakening.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same journal

Increased rates of hybridization in swordtails are associated with water pollution.

Current biology : CB·2026
Same journal

Visual uncertainty and task demands shape active sensing strategies in mice.

Current biology : CB·2026
Same journal

An adaptable, self-organizing, single-cell morphology circuit optimizes suctorian predatory trap structure.

Current biology : CB·2026
Same journal

Temporal tuning of switch-like virulence expression resolves environmental uncertainty through phenotypic heterogeneity.

Current biology : CB·2026
Same journal

An abstract relational map emerges in the human medial prefrontal cortex with consolidation.

Current biology : CB·2026
Same journal

Phloem evolved gradually and asynchronously to xylem in early vascular plants.

Current biology : CB·2026
See all related articles

Related Experiment Video

Updated: Oct 12, 2025

Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

24.4K

Noradrenaline: Sleep on it.

Noa Matosevich1, Yuval Nir2

  • 1Sagol School of Neuroscience, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo 69978, Israel.

Current Biology : CB
|November 23, 2021
PubMed
Summary
This summary is machine-generated.

The brain's noradrenaline system regulates sleep by influencing thalamic activity and heart rate. This system controls slow brain fluctuations between disengagement and sensory reactivity during sleep.

More Related Videos

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats
07:04

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

Published on: August 19, 2018

10.7K
Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
08:08

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

27.2K

Related Experiment Videos

Last Updated: Oct 12, 2025

Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

24.4K
A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats
07:04

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

Published on: August 19, 2018

10.7K
Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
08:08

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

27.2K

Area of Science:

  • Neuroscience
  • Sleep Science
  • Physiology

Background:

  • Sleep is characterized by infra-slow fluctuations (∼50-second cycles) alternating between states of disengagement and sensory reactivity.
  • The precise neural mechanisms governing these sleep dynamics remain incompletely understood.

Purpose of the Study:

  • To investigate the role of the noradrenaline system in regulating infra-slow sleep fluctuations.
  • To elucidate how noradrenaline influences thalamic activity, sleep spindles, and heart rate variability during sleep.

Main Methods:

  • Utilized advanced neuroimaging and physiological monitoring techniques.
  • Investigated the effects of noradrenaline modulation on brain activity and autonomic functions during sleep.

Main Results:

  • Demonstrated that the noradrenaline system is a key regulator of infra-slow sleep dynamics.
  • Showed that noradrenaline acts in the thalamus to modulate sleep spindles.
  • Revealed that noradrenaline influences coordinated heart rate variations during sleep.

Conclusions:

  • The noradrenaline system plays a critical role in orchestrating the cyclical changes in brain state during sleep.
  • Findings provide new insights into the neural control of sleep architecture and autonomic regulation.