Related Experiment Video
Updated: Oct 12, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Personality traits in acromegalic patients: Comparison with patients with non-functioning adenomas and healthy
Elif Kilic Kan1, Aysegul Atmaca1, Gokhan Sarisoy2
1Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayis University Medical of School, Samsun 55200, Turkey.
Objectives:
Pituitary diseases may cause psychiatric and personality alterations. We aimed to compare the personality traits of acromegalic patients with those of patients with non-functioning pituitary adenomas and a healthy control group.
Design:
Fifty-eight acromegalic patients, 45 patients with non-functioning adenoma, and 40 healthy subjects were enrolled in the study. Cloninger's Temperament and Character Inventory (TCI), Beck Depression Inventory, Beck Anxiety Inventory, and Rosenberg Self-Esteem Scale (RSES) were used to assess personality, depression, anxiety, and self-esteem.
Results:
Depression score was higher in acromegaly and non-functioning adenoma groups than healthy controls. RSES scores were similar among the three groups. Regarding the scales of TCI, only novelty-seeking was significantly reduced in acromegaly and non-functioning adenoma than the control group. Pairwise comparisons revealed that the difference was due to the difference between acromegalic patients and controls. Scales of TCI were correlated with depression and anxiety in patients with acromegaly and non-functioning adenoma but not in healthy controls.
Conclusion:
This study showed that novelty-seeking was reduced in patients with acromegaly. Both the hormonal lack and excess and structural changes can lead to cognitive and personality changes in acromegaly. More studies are needed to be carried out about personality characteristics in pituitary diseases.
Related Concept Videos
Personality Disorders: Narcissistic and Avoidant
Characteristics of Narcissistic Personality Disorder
Narcissistic individuals exhibit an inflated sense of self-importance and an excessive need for admiration. They are often...
Factors Influencing Attraction VI: Personality Traits
Personality Theory by Eysenck and Eysenck
In the extroversion/introversion dimension, highly extroverted people are sociable, outgoing, and easily connect with others. In contrast,...
Self-Report Tests of Personality
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Dark Triad and Person Perception

