The Relationship Between Intolerance of Uncertainty and Psychological Resilience with Quality of Life in Patients...

This study aimed to examine the relationship between intolerance of uncertainty (IU), psychological resilience (PR), and quality of life (QoL) in patients with obsessive-compulsive disorder (OCD).

A total of 144 participants (72 patients with OCD and 72 matched healthy controls) were included. Participants completed the Intolerance of Uncertainty Scale (IUS), the Resilience Scale for Adults (RSA), the Short-Form 36 (SF-36), the Hamilton Anxiety Rating Scale (HARS), the Hamilton Depression Rating Scale (HDRS), and the Yale- Brown Obsessive Compulsive Scale (Y-BOCS).

The groups were matched for age, gender, and socioeconomic status (p>0.05). The OCD group had significantly higher IU scores and lower QoL scores across all SF-36 domains compared to controls. In the OCD group, all QoL subscales showed a significant negative correlation with total IUS scores (strongest for vitality: r=-0.676, p<0.001) and a significant positive correlation with total RSA scores (strongest for vitality: r=0.619, p<0.001). Regression analyses indicated that PR, illness duration, and symptom severity (Y-BOCS) were significant predictors of QoL, explaining 15.9% to 55.3% of the variance in key mental health-related QoL domains.

QoL in OCD patients is significantly impaired compared to healthy individuals. This impairment is strongly associated with higher IU, lower psychological resilience, and greater symptom severity.