Related Experiment Video

Updated: Oct 12, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.3K

Genetic association analysis between IL9 and coronary artery disease in a Chinese Han population

Lingfeng Zha1, Jiangtao Dong2, Qianwen Chen3

  • 1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Cytokine
|November 23, 2021
PubMed

Insights

Interleukin-9 (IL-9) gene variations are linked to coronary artery disease (CAD) risk. Specific IL9 gene variants and haplotypes influence CAD development and lipid levels, suggesting a role in disease prevention.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Immunology

Background:

  • Interleukin-9 (IL-9) is implicated in cardiovascular health.
  • The precise genetic association between IL-9 and coronary artery disease (CAD) remains under-investigated.
  • Understanding IL-9's role could offer new therapeutic targets for CAD.

Purpose of the Study:

  • To investigate the association between single nucleotide polymorphisms (SNPs) in the IL9 gene and CAD in a Chinese Han population.
  • To explore the relationship between IL9 genetic variations and traditional cardiovascular risk factors.

Main Methods:

  • Case-control study involving 3704 individuals (1863 CAD patients, 1841 controls).
  • Analysis of four tag SNPs within the IL9 gene: rs31563, rs2069868, rs2069870, and rs31564.
  • Statistical analyses including adjusted p-values (Padj) for association testing and haplotype analysis.

Main Results:

  • The SNP rs2069868 showed a significant association with CAD in hypertensive patients (Padj = 0.027).
  • The IL9 haplotype CGAT was associated with an increased risk of CAD (Padj = 0.035).
  • A specific genotype combination (rs31563_CC/rs31564_TT) significantly reduced CAD risk (Padj = 0.001).
  • SNP rs2069870 correlated with lower LDL-c and total cholesterol, while rs31563 correlated with higher HDL-c levels (Padj < 0.05).

Conclusions:

  • IL9 genetic variations are associated with coronary artery disease risk and lipid profiles.
  • IL-9 may play a causal role in CAD pathogenesis through interactions with traditional risk factors.
  • These findings suggest IL9 as a potential target for novel CAD prevention and treatment strategies.

Keywords:
Association analysisCoronary artery disease (CAD)HaplotypeIL9Single-nucleotide polymorphisms (SNPs)

More Related Videos

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq09:52

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq

Published on: April 19, 2013

24.5K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.6K

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.7K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
16.8K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
476
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
79
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
43