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Quantitative MRI Differences Between Early versus Late Onset Alzheimer's Disease.
Somayeh Meysami1, Cyrus A Raji2, David A Merrill3,4
1Department of Neurology, 21767David Geffen School of Medicine at University of California, Los Angeles, CA, USA.
American Journal of Alzheimer'S Disease and Other Dementias
|November 24, 2021
Summary
Early onset Alzheimer's Disease (EOAD) shows distinct brain atrophy patterns compared to late onset AD (LOAD). Parietal lobe volume is a key differentiator, aiding in early diagnosis.
Area of Science:
- Neurology
- Neuroimaging
- Alzheimer's Disease Research
Background:
- Early onset Alzheimer's Disease (EOAD) (<65 years) exhibits different tau deposition and network involvement than late onset Alzheimer's Disease (LOAD) (≥65 years).
- Understanding neuroanatomical differences is crucial for distinguishing between EOAD and LOAD.
Purpose of the Study:
- To investigate if clinical brain MRI volumes can differentiate between EOAD and LOAD.
- To identify specific brain regions indicative of EOAD.
Main Methods:
- Quantitative volumetric analysis of T1 MRI scans from 45 EOAD patients and 32 LOAD patients.
- Receiver operating curve (ROC) analysis to assess diagnostic accuracy.
Main Results:
- EOAD patients exhibited significantly smaller parietal lobe volumes compared to LOAD patients.
- LOAD patients showed smaller left putamen and hippocampus volumes.
- ROC analysis achieved 96.5% Area Under the Curve for differentiating EOAD from LOAD based on brain regions.
Conclusions:
- Parietal lobe atrophy, particularly less than 30% of normal volume, is suggestive of EOAD.
- Clinical MRI volumetric analysis can effectively distinguish EOAD from LOAD.
