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Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

Chen Xue1, Ganglei Li2, Juan Lu1

  • 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.

Signal Transduction and Targeted Therapy
|November 24, 2021
PubMed

Insights

Circular RNAs (circRNAs) interact with the PI3K/AKT pathway, influencing cancer gene expression and progression. This review details circRNA roles in cancer diagnosis, prognosis, and treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are noncoding RNAs with regulatory functions in gene expression.
  • The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway is crucial for cell functions and cancer progression.

Purpose of the Study:

  • To review the expression and functions of PI3K-AKT-related circRNAs in cancer.
  • To assess the association of these circRNAs with clinicopathological characteristics.
  • To discuss the role of circRNAs in cancer diagnosis, prognosis, and treatment.

Main Methods:

  • Literature review of studies on circRNAs and the PI3K/AKT pathway in cancer.
  • Summary of in vitro and in vivo experimental findings.
  • Analysis of associations with clinicopathological data.

Main Results:

  • The circRNA/PI3K/AKT axis modulates cancer-associated genes and tumor progression.
  • Aberrant circRNA expression correlates with clinicopathological features.
  • circRNAs play significant roles in biological functions relevant to cancer.

Conclusions:

  • circRNAs are key regulators in the PI3K/AKT pathway, impacting cancer.
  • circRNAs hold potential as diagnostic, prognostic, and therapeutic targets in oncology.

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