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Association between CDK8 gene polymorphisms and dilated cardiomyopathy in a Chinese Han population

Ran Zhang1, Yue Zhong1, Si-Yu Long2

  • 1Department of Cardiology, West China Hospital of Sichuan University, Chengdu, China.

Cardiovascular Diagnosis and Therapy
|November 24, 2021
PubMed

Insights

This study found that specific polymorphisms in the Cyclin-dependent-kinase 8 (CDK8) gene are associated with an increased risk of dilated cardiomyopathy (DCM) and poorer prognosis in the Chinese Han population.

Area of Science:

  • Genetics
  • Cardiology
  • Molecular Biology

Background:

  • Dilated cardiomyopathy (DCM) is a common heart condition with unclear pathogenesis.
  • The Cyclin-dependent-kinase 8 (CDK8) gene plays a role in transcription and signaling pathways.

Purpose of the Study:

  • To investigate the association between CDK8 gene polymorphisms and DCM susceptibility.
  • To explore the impact of CDK8 gene polymorphisms on DCM prognosis in the Chinese Han population.

Main Methods:

  • Genotyping of two CDK8 single nucleotide polymorphisms (SNPs): rs17083838 and rs7992670 using PCR-RFLP.
  • Analysis of 341 DCM patients and 381 healthy controls.
  • Survival analysis using Kaplan-Meier curves and Cox regression.

Main Results:

  • Increased frequencies of allele A for both rs17083838 and rs7992670 in DCM patients compared to controls.
  • CDK8 polymorphisms were significantly associated with DCM susceptibility.
  • Specific genotypes of rs17083838 and rs7992670 correlated with poor prognosis in DCM patients, even after adjusting for clinical factors.

Conclusions:

  • CDK8 gene polymorphisms are potentially linked to both the susceptibility and prognosis of DCM.
  • This is the first study to demonstrate this association in the Chinese Han population.
Abstract

Keywords:
CDK8Dilated cardiomyopathy (DCM)polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)single nucleotide polymorphism (SNP)survival analysis

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