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Multiple autoimmunity and epitope spreading in monozygotic twins
Esperanza Avalos-Díaz1, Elena Pérez-Pérez1, Julio Granados2
1Universidad Autónoma de Zacatecas, Department of Immunology, UACB. Guadalupe, Zac, Mexico.
Abstract:
We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here.
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