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Related Concept Videos

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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Related Experiment Video

Updated: Oct 12, 2025

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins
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Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins

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RNA modifications as emerging therapeutic targets.

Akin Cayir1,2

  • 1Vocational Health College, Canakkale Onsekiz Mart University, Canakkale, Turkey.

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RNA modifications, crucial for cellular processes, are increasingly linked to diseases. Targeting these RNA changes and their regulatory genes offers promising new therapeutic strategies for drug development.

Keywords:
RNA modificationsRNA modifying genesdrug discoverym6A

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Area of Science:

  • Molecular Biology
  • Genetics
  • Pharmacology

Background:

  • The epitranscriptome, encompassing RNA posttranscriptional modifications, plays a significant role in various diseases.
  • Over 170 types of RNA modifications have been identified, highlighting their diverse biological functions.
  • Regulatory genes involved in RNA modification are implicated in critical biological processes and disease pathogenesis.

Purpose of the Study:

  • To comprehensively review RNA modifications and their regulatory genes in the context of drug development.
  • To summarize existing research on targeting RNA modifications for therapeutic interventions.
  • To explore the potential of RNA modifications as emerging therapeutic targets.

Main Methods:

  • Literature review and synthesis of previous studies on RNA modifications and drug development.
  • Analysis of regulatory genes associated with RNA modifications and their roles in disease.
  • Discussion of molecular mechanisms for targeting RNA modifications and regulatory genes.

Main Results:

  • RNA modifications are increasingly recognized for their involvement in disease development.
  • Inhibitors targeting RNA modification regulatory genes demonstrate therapeutic potential.
  • A growing body of evidence supports RNA modifications as viable targets for new drug development.

Conclusions:

  • RNA modifications and their regulatory genes represent a promising frontier for novel therapeutic strategies.
  • Targeting specific RNA modifications or regulatory pathways can offer new avenues for disease treatment.
  • Further research into the epitranscriptome holds significant potential for advancing drug discovery and development.