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Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights
Ammad Ahmad Farooqi1, Fatima Tahir2, Maham Fakhar3
1Department of Molecular Oncology, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan. Farooqiammadahmad@gmail.com.
Abstract:
The growing complexity of metastasis has sparked tremendous interest in unraveling of the underlying mechanisms which play fundamental role in cancer progression and metastasis. Ground-breaking discoveries in metastasis research have greatly enhanced our understanding about intricate nature of metastasis. Bioactive chemicals obtained from citrus fruits have gained noteworthy appreciation because of significant cancer chemopreventive roles. Deregulated oncogenic signaling cascades play central role in metastasis. Emerging evidence has started to shed light on the metastasis inhibitory properties of naringin, naringenin, tangeretin, nobiletin, hesperidin and hesperetin in different cancer cell lines and xenografted mice. Wnt/?-catenin, TGF/SMAD and NOTCH signaling cascades have been shown to play linchpin role in carcinogenesis and metastasis. There is emerging evidence related to pharmacological targeting of Wnt/?-catenin, TGF/SMAD and NOTCH by citrus-derived bioactive components. These findings are indeed encouraging and will enable researchers to gain further insights into pharmacological targeting of oncogenic pathways to inhibit and prevent metastasis.
Insights
Citrus fruit compounds like naringin and nobiletin show promise in inhibiting cancer metastasis. These natural compounds target key signaling pathways (Wnt/β-catenin, TGF/SMAD, NOTCH) involved in cancer progression.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Metastasis is a complex process crucial to cancer progression.
- Bioactive compounds from citrus fruits exhibit significant cancer chemopreventive properties.
- Deregulated oncogenic signaling pathways are central to metastasis.
Purpose of the Study:
- To explore the metastasis inhibitory effects of citrus-derived bioactive components.
- To investigate the role of these compounds in targeting key oncogenic signaling pathways.
- To provide insights into novel therapeutic strategies for preventing and inhibiting cancer metastasis.
Main Methods:
- Review of emerging evidence on citrus-derived compounds (naringin, naringenin, tangeretin, nobiletin, hesperidin, hesperetin).
- Analysis of their effects in various cancer cell lines and xenografted mouse models.
- Examination of their impact on Wnt/β-catenin, TGF/SMAD, and NOTCH signaling cascades.
Main Results:
- Citrus-derived compounds demonstrate metastasis inhibitory properties.
- These compounds show potential in targeting critical oncogenic pathways like Wnt/β-catenin, TGF/SMAD, and NOTCH.
- Evidence suggests their efficacy in both in vitro and in vivo cancer models.
Conclusions:
- Citrus-derived bioactive components offer a promising avenue for developing metastasis inhibitors.
- Targeting oncogenic pathways with these natural compounds could lead to new cancer prevention and treatment strategies.
- Further research into these compounds will enhance understanding and application in oncology.
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