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Two-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms
Zhiwen Yan1,2,3, Cheng Chen1, Gonzalo Rosso4,5,6
1Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Frontiers in Bioengineering and Biotechnology
|November 25, 2021
Summary
Two-dimensional nanomaterials enhance peripheral nerve regeneration by promoting blood vessel formation. This review explores how these nanomaterials support nerve repair and functional recovery after injury.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Peripheral nerve regeneration is limited despite advances in biomaterials.
- Two-dimensional nanomaterials show promise in improving nerve scaffold efficacy.
Purpose of the Study:
- To review the role of two-dimensional nanomaterials in peripheral nerve regeneration.
- To investigate if these nanomaterials promote angiogenesis for nerve repair.
Main Methods:
- Summarize events following peripheral nerve injury.
- Discuss two-dimensional nanomaterial applications in nerve regeneration strategies.
- Analyze the mechanisms of capillary support for neuronal regeneration.
Main Results:
- Two-dimensional nanomaterials facilitate angiogenesis, promoting peripheral nerve regeneration.
- Newly formed capillaries support neuronal regeneration directionally and metabolically.
Conclusions:
- Two-dimensional nanomaterials are a potential solution for long peripheral nerve defects.
- Addressing energy deficiency post-injury can further enhance therapeutic effects.
