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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Oct 12, 2025

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
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Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

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Structural abnormalities associated with glaucoma using swept-source optical coherence tomography in patients with

Cecilia Victoria Agapito Tito1, Juliana Silvatti1, Izabela N F de Almeida2

  • 1Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Botucatu 740, 3° andar, São Paulo, SP, 04023-062, Brazil.

International Ophthalmology
|November 25, 2021
PubMed
Summary

Systemic sclerosis (SSc) patients show thinner retinal nerve fiber layer (RNFL) thickness, indicating early ganglion cell damage. Monitoring ocular health is crucial for these patients.

Keywords:
Normal-tension glaucomaOptical coherence tomographyRetinal nerve fibre layer thicknessSystemic sclerosis

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Vascular Biology

Background:

  • Vasospasm is an early feature of systemic sclerosis (SSc).
  • Ocular vasospasm can lead to optic nerve head (ONH) damage, contributing to normal-tension glaucoma (NTG) pathogenesis.
  • Investigating early ocular structural changes in SSc is vital.

Purpose of the Study:

  • To detect structural abnormalities associated with NTG in SSc patients using swept-source optical coherence tomography (SS-OCT).
  • To correlate SS-OCT parameters with clinical, capillaroscopy, and digital blood flow measures in SSc patients.

Main Methods:

  • A cross-sectional study involving 40 SSc patients and 23 age-matched controls.
  • SS-OCT was used to measure retinal nerve fiber layer (RNFL) thickness, macular ganglion cell layer complex (GCC) thickness, and ONH morphology.
  • Nailfold capillaroscopy (NFC) and laser Doppler imaging (LDI) for digital blood flow were performed.

Main Results:

  • SSc patients exhibited significantly thinner temporal RNFL compared to controls (p=0.001).
  • Disease duration and Raynaud's phenomenon duration inversely correlated with RNFL and GCC thickness in SSc patients (p<0.05).
  • NFC and LDI measurements did not correlate with OCT parameters.

Conclusions:

  • Thinner temporal RNFL and correlations with disease/Raynaud's duration suggest early ganglion cell damage in SSc.
  • These SS-OCT findings highlight the presence of subclinical ocular abnormalities in SSc.
  • Regular monitoring for ocular complications is recommended for SSc patients.