Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

What are the experiences of families whose child uses a robotic walker in their home environment? A qualitative study.

Disability and rehabilitation. Assistive technology·2026

Same author

Sport versus Nonsport Injury Setting as a Moderator of Postconcussive Symptoms Following Pediatric Concussion: An Advancing Concussion Assessment in Pediatrics Study.

The Journal of pediatrics·2026

Same author

Implementation strategies for early hand therapy for young children with cerebral palsy.

Developmental medicine and child neurology·2026

Same author

Creating an engaging brain computer interface, electrical stimulation therapy for children with hemiparesis: a pilot study.

Journal of neuroengineering and rehabilitation·2026

Same author

Performance validity tests in a large racially and linguistically diverse pediatric and young adult clinical sample: Investigations of the TOMM, MVP, and MSVT.

The Clinical neuropsychologist·2026

Same author

The Relationship Between Inhibitory Control of Attention and fMRI Functional Connectivity in Children With and Without ADHD.

Journal of attention disorders·2026

Search research articles

Related Experiment Video

Updated: Oct 12, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Frontal interhemispheric structural connectivity, attention, and executive function in children with perinatal

Nicole Larsen¹, Brandon T Craig^1,2,3,4, Alicia J Hilderley^1,2,3,4

¹Calgary Pediatric Stroke Program, Alberta Children's Hospital, Calgary, Canada.

Brain and Behavior

|November 26, 2021

Summary

Perinatal stroke in children is linked to Attention Deficit/Hyperactivity Disorder (ADHD) and executive dysfunction. Diffusion imaging reveals altered frontal white matter microstructure, correlating with poorer cognitive and behavioral outcomes in affected children.

Keywords:

ADHD cerebral palsy diffusion tensor imaging executive function perinatal stroke tractography

More Related Videos

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Related Experiment Videos

Last Updated: Oct 12, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Area of Science:

Neuroscience
Pediatric Neurology
Radiology

Background:

Perinatal stroke impacts approximately 1 in 1000 births, frequently leading to cognitive impairments.
Attention Deficit/Hyperactivity Disorder (ADHD) and executive dysfunction are significantly more common in children with perinatal stroke.

Purpose of the Study:

To investigate the relationship between frontal white matter (WM) microstructure differences and cognitive impairments in children with perinatal stroke.
To explore if diffusion imaging metrics of frontal WM can serve as biomarkers for cognitive and behavioral outcomes.

Main Methods:

Used diffusion imaging and tractography to isolate and analyze the anterior forceps in 83 children (26 arterial ischemic stroke, 26 periventricular venous infarction, 31 controls).
Quantified frontal WM microstructure using along-tract analyses.
Correlated WM metrics with parent ratings of ADHD symptoms (ADHD-5) and executive functioning (BRIEF).

Main Results:

Stroke groups exhibited altered frontal WM microstructure compared to controls.
Differences in WM metrics were observed both near the lesion site and in remote areas, including the nonlesioned hemisphere.
Higher white matter diffusivity values correlated with increased ADHD symptoms and poorer executive function.

Conclusions:

Frontal white matter microstructure, as assessed by diffusion imaging and tractography, is altered in children with perinatal stroke.
These microstructural changes are associated with significant cognitive and behavioral deficits, including ADHD and executive dysfunction.
Frontal WM microstructure may serve as a valuable biomarker for understanding and potentially predicting cognitive and behavioral outcomes in perinatal stroke survivors.