Recent progress in the oxidative coupling of unactivated Csp3-H bonds with other C-H bonds
Yang Liao1, Feng Liu1, Zhang-Jie Shi1
1Department of Chemistry, Fudan University, 2005 Songhu Rd, Shanghai, 200438, China. liufeng@fudan.edu.cn.
Abstract:
The oxidative coupling between two carbon-hydrogen (C-H) bonds offers the most straightforward pathway to construct C-C bonds from hydrocarbons without pre-functionalization, exhibiting high step- and atom-economy. This article features the recent advances in the oxidative coupling of unactivated Csp3-H with different hybrid C-H bonds, including Csp-H, Csp2-H and Csp3-H bonds. The substrate scope, proposed mechanism and application of these reactions are summarized, intending to provide insights toward developing novel and efficient protocols for Csp3-C bond construction.
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