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Published on: April 22, 2016
Recent Advances in Biotransformation by Cunninghamella Species
Manoela Daiele Gonçalves1, Fernanda Tomiotto-Pellissier2, Ricardo Luís Nascimento de Matos1
1Laboratory of Biotransformation and Phytochemistry, Department of Chemistry, Center of Exact Sciences and Department of Pharmaceutical Sciences, Center of Health Sciences, State University of Londrina,Brazil.
Abstract:
The goal of the biotransformation process is to develop structural changes and generate new chemical compounds, which can occur naturally in mammalian and microbial organisms, such as filamentous fungi, and represent a tool to achieve enhanced bioactive compounds. Cunninghamella spp. is among the fungal models most widely used in biotransformation processes at phase I and II reactions, mimicking the metabolism of drugs and xenobiotics in mammals and generating new molecules based on substances of natural and synthetic origin. Therefore, the goal of this review is to highlight the studies involving the biotransformation of Cunninghamella species between January 2015 and March 2021, in addition to updating existing studies to identify the similarities between the human metabolite and Cunninghamella patterns of active compounds, with related advantages and challenges, and providing new tools for further studies in this scope.
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