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Translating Therapeutic Microgels into Clinical Applications.
Yonca Kittel1, Alexander J C Kuehne1,2,3, Laura De Laporte1,4,5
1DWI - Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52074, Aachen, Germany.
Advanced Healthcare Materials
|November 26, 2021
Summary
Microgels are versatile biocompatible networks with tunable properties for diverse clinical uses. This review details their fabrication, applications in drug delivery and tissue engineering, and clinical potential.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Nanotechnology
Background:
- Microgels are crosslinked, water-swollen polymer networks (10 nm–100 µm) offering tunable properties.
- Chemical and biological modifications enhance microgel biocompatibility for clinical applications.
- Mechanical and structural properties are engineered via composition, crosslinking, and fabrication.
Purpose of the Study:
- To review fundamental aspects of microgel research and development.
- To discuss microgel applications in clinical theranostics and therapy.
- To provide a guideline for researchers on microgel fabrication, characterization, and functionalization.
Main Methods:
- Overview of microgel fabrication techniques relevant to clinical applications.
- Discussion of microgel roles in drug delivery, scavenging, and as contrast agents.
- Exploration of microgels as scaffolds for tissue engineering and regeneration.
Main Results:
- Microgels demonstrate potential in local drug delivery, acting as scavengers, and as contrast agents.
- They serve as scaffolds for tissue engineering and regenerative medicine.
- Several microgel formulations have advanced to pre-clinical and clinical trials.
Conclusions:
- Microgels offer significant promise for advanced clinical applications, including theranostics and therapy.
- Further research and development are crucial to overcome challenges and realize their full potential.
- This review guides scientists in leveraging microgels from fabrication to clinical translation.
