Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fungal Group Zygomycota

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The small non-coding RNA, RsaC, is essential for Staphylococcus aureus virulence.

The Journal of infectious diseases·2026

Same author

Tracking Plasmodium knowlesi Through Fecal DNA for Monitoring Zoonotic Transmission in Wild Macaques Across Southeast and South Asia.

The Journal of infectious diseases·2026

Same author

Impact of Tryptophan Positional Isomerism on Physicochemical and Biological Properties: A Case Study Using Gramicidin A Analogs.

JACS Au·2025

Same author

Genome Mining-Based Discovery of Pyrano[2,3-<i>c</i>]pyrrole Type Natural Products Possessing Alkyl Side Chain with Branched Methyl Groups.

Organic letters·2025

Same author

Immune modulation and improved systemic performance of phosphate-functionalized nanogels for antifungal therapy.

Drug discoveries & therapeutics·2025

Same author

Streptococcus pyogenes Surveillance Through Surface Swab Samples to Track the Emergence of Streptococcal Toxic Shock Syndrome in Rural Japan.

The Journal of infectious diseases·2025

Search research articles

Related Experiment Video

Updated: Oct 12, 2025

The Galleria mellonella Waxworm Infection Model for Disseminated Candidiasis

The Galleria mellonella Waxworm Infection Model for Disseminated Candidiasis

Published on: November 17, 2018

Novel Pathogenic Mucorales Identified Using the Silkworm Infection Model.

Suresh Panthee¹, Hiroshi Hamamoto², Yayoi Nishiyama²

¹Drug Discoveries by Silkworm Models, Faculty of Pharma-Science, Teikyo University, Hachioji, Tokyo 192-0395, Japan.

Journal of Fungi (Basel, Switzerland)

|November 27, 2021

Summary

Researchers identified four new pathogenic Mucorales fungi using a silkworm model. This discovery aids in understanding and combating mucormycosis, a dangerous infection often linked to COVID-19.

Keywords:

COVID-19 Mucorales animal-model opportunistic infection silkworm

More Related Videos

The Insect Galleria mellonella as a Powerful Infection Model to Investigate Bacterial Pathogenesis

The Insect Galleria mellonella as a Powerful Infection Model to Investigate Bacterial Pathogenesis

Published on: December 11, 2012

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions

Published on: October 18, 2017

Related Experiment Videos

Last Updated: Oct 12, 2025

The Galleria mellonella Waxworm Infection Model for Disseminated Candidiasis

The Galleria mellonella Waxworm Infection Model for Disseminated Candidiasis

Published on: November 17, 2018

The Insect Galleria mellonella as a Powerful Infection Model to Investigate Bacterial Pathogenesis

The Insect Galleria mellonella as a Powerful Infection Model to Investigate Bacterial Pathogenesis

Published on: December 11, 2012

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions

The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions

Published on: October 18, 2017

Area of Science:

Mycology
Infectious Diseases
Environmental Microbiology

Background:

Mucormycosis is a rare, fatal fungal infection caused by Mucorales.
These fungi are increasingly linked to COVID-19 patients due to their virulence factors.
Identifying novel Mucorales is crucial for developing effective treatment strategies.

Purpose of the Study:

To identify novel pathogenic Mucorales from the environment.
To establish an invertebrate model for screening pathogenic fungi.
To investigate the pathogenicity of newly identified strains.

Main Methods:

Utilized the silkworm (Bombyx mori) model for fungal screening.
Performed phylogenetic analysis using LSU rRNA and ITS gene sequencing.
Assessed fungal growth under various conditions and pathogenicity in immunocompromised mice.

Main Results:

Identified four novel pathogenic Mucorales strains.
Phylogenetic analysis placed strains with Mucor orantomantidis and Backusella lamprospora.
Demonstrated pathogenicity in silkworms and immunocompromised mice, with a cold-sensitive phenotype.

Conclusions:

The silkworm model is effective for identifying novel pathogenic Mucorales.
New strains exhibit pathogenicity and cold-sensitive growth.
Findings contribute to understanding COVID-19-associated mucormycosis.