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07:24
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
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Fungal Endophthalmitis: A Comprehensive Review
Abid A Haseeb1, Abdelrahman M Elhusseiny2, Mohammad Z Siddiqui2
1Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Journal of Fungi (Basel, Switzerland)
|November 27, 2021
Summary
Fungal endophthalmitis, often caused by Candida albicans, leads to vision loss. Prompt diagnosis and treatment with antifungal medications and potential surgery are crucial for preserving sight.
Area of Science:
- Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Endophthalmitis is severe intraocular inflammation, typically bacterial or fungal.
- Infectious endophthalmitis enters the eye exogenously (trauma, surgery) or endogenously (bloodstream).
- Candida albicans is the most common cause of fungal endophthalmitis.
Purpose of the Study:
- To review the essential elements of understanding fungal endophthalmitis.
- To highlight fungal endophthalmitis as a clinically relevant, vision-threatening entity.
Main Methods:
- This review synthesizes current knowledge on fungal endophthalmitis.
- Diagnosis relies on clinical presentation supported by cultures (vitreous, aqueous, blood).
Main Results:
- Fungal endophthalmitis commonly manifests as vision loss.
- Inflammation and infection signs are frequent clinical findings.
Conclusions:
- Fungal endophthalmitis requires prompt diagnosis and management.
- Treatment includes systemic and intravitreal antifungals, and possibly pars plana vitrectomy.
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