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Impact of the Innate Inflammatory Response on ICU Admission and Death in Hospitalized Patients with COVID-19

Jorge Monserrat1,2, Angel Asunsolo2,3,4, Ana Gómez-Lahoz1,2

  • 1Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain.

Biomedicines
|November 27, 2021
PubMed

Insights

Elevated levels of certain cytokines and growth factors, including interleukin-10 (IL-10), interleukin-6 (IL-6), and granulocyte-colony stimulating factor (GCSF), predict intensive care unit (ICU) admission and death in severe COVID-19 patients.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Severe COVID-19 is associated with a dysregulated immune response.
  • Identifying biomarkers for predicting disease severity is crucial for patient management.

Purpose of the Study:

  • To evaluate the predictive capacity of various cytokines and growth factors for ICU admission and mortality in severe COVID-19 patients.

Main Methods:

  • Retrospective cohort study of 287 hospitalized COVID-19 patients.
  • Serum levels of 62 immune response mediators were measured using Luminex Multiplex assay within six days of admission.
  • Patients were followed for ICU admission and/or death.

Main Results:

  • Increased serum levels of IL-6, IL-15, sRAGE, IP10, MCP3, sIL1RII, IL-8, GCSF, MCSF, and IL-10 were linked to ICU admission and/or death.
  • The combination of IL-10, IL-6, and GCSF demonstrated the strongest prognostic value.

Conclusions:

  • Severe COVID-19 leading to ICU admission or death is characterized by elevated inflammatory cytokines and chemokines.
  • Serum IL-10, IL-6, and GCSF levels are highly prognostic for severe COVID-19 outcomes.
Abstract

Keywords:
COVID-19ICUSARS-CoV-2cytokinesinnate inflammatory response

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