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Updated: Oct 12, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity
Corina Popovici1,2, Cristina-Maria Pavel3, Valeriu Sunel1
1Faculty of Chemistry, Alexandru Ioan Cuza University, 11 Carol I Blvd., 700506 Iasi, Romania.
Abstract:
Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives' applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and 1H NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against Mycobacterium tuberculosis.
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