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Updated: Oct 12, 2025

Author Spotlight: Decoding Mitochondrial Aging
Published on: June 30, 2023
Acetylation in Mitochondria Dynamics and Neurodegeneration
Jaylyn Waddell1, Aditi Banerjee1, Tibor Kristian2,3
1Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Abstract:
Mitochondria are a unique intracellular organelle due to their evolutionary origin and multifunctional role in overall cellular physiology and pathophysiology. To meet the specific spatial metabolic demands within the cell, mitochondria are actively moving, dividing, or fusing. This process of mitochondrial dynamics is fine-tuned by a specific group of proteins and their complex post-translational modifications. In this review, we discuss the mitochondrial dynamics regulatory enzymes, their adaptor proteins, and the effect of acetylation on the activity of fusion and fission machinery as a ubiquitous response to metabolic stresses. Further, we discuss the role of intracellular cytoskeleton structures and their post-translational modifications in the modulation of mitochondrial fusion and fission. Finally, we review the role of mitochondrial dynamics dysregulation in the pathophysiology of acute brain injury and the treatment strategies based on modulation of NAD+-dependent deacetylation.
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