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Updated: Oct 12, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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The Interface between Cell Signaling Pathways and Pregnane X Receptor

Robert S Rogers1, Annemarie Parker1, Phill D Vainer1

  • 1Division of Basic Sciences, Farber-McIntire Campus, College of Osteopathic Medicine, Kansas City University, Joplin, MO 64804, USA.

Cells
|November 27, 2021
PubMed
Summary

Pregnane X receptor (PXR) regulates drug metabolism and interactions. Recent studies reveal how PXR post-translational modifications (PTMs) influence its function and gene expression, impacting therapeutic strategies.

Keywords:
PARylationSUMOylationacetylationcell signalingnuclear receptorphosphorylationpregnane X receptorubiquitinationxenobiotics

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