Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Bone Matrix01:18

The Bone Matrix

4.8K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microbiota-derived indole derivatives as anticancer agents: mechanistic insights and major perspectives.

Future microbiology·2026
Same author

Biomimetic Nanoparticles for Targeted and Efficient Cancer Therapy: Progress, Challenges and Perspectives.

International journal of nanomedicine·2026
Same author

Xanthan Gum-Driven Innovations for Reinventing Food Preservation.

Polymers·2025
Same author

Harnessing Starch for Next-Generation Corneal Tissue Engineering.

ACS biomaterials science & engineering·2025
Same author

Artificial Intelligence-Based Wearable Sensing Technologies for the Management of Cancer, Diabetes, and COVID-19.

Biosensors·2025
Same author

Advances in three-dimensional hydrogel networks for cancer immunotherapy.

Journal of materials chemistry. B·2025
Same journal

Correction: Jiménez-Sánchez et al. Antioxidant Enzymes Genetic Variants Associated with Urticaria/Angioedema Induced by Cross-Reactive Hypersensitivity to Nonsteroidal Anti-Inflammatory Drugs. <i>Pharmaceuticals</i> 2026, <i>19</i>, 522.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

Correction: Zhao et al. Multifunctional Gel Films of Marine Polysaccharides Cross-Linked with Poly-Metal Ions for Wound Healing. <i>Pharmaceuticals</i> 2022, <i>15</i>, 750.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

Intravenous Immunoglobulin Reveals a Novel Protective Mechanism: Targeting the GBP5-Driven Pyroptosis Axis in Experimental Colitis.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

Icariin Attenuates Renal Injury in Streptozotocin-Induced Diabetic Rats with and Without Adenine-Induced Chronic Kidney Disease.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

AI-Assisted Identification of a Putative Allosteric Ligand Targeting the CDK4/Cyclin D1 Protein-Protein Interface.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

Development and Study of Hydrophilic Ointment Compositions with a Dextrin/Polyvinyl Alcohol/Iodine Complex (D/PVA/I).

Pharmaceuticals (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Oct 12, 2025

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

3.9K

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering.

Anand Mohan1, Madhuri Girdhar1, Raj Kumar2

  • 1School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, India.

Pharmaceuticals (Basel, Switzerland)
|November 27, 2021
PubMed
Summary
This summary is machine-generated.

Polyhydroxybutyrate (PHB)/organically modified montmorillonite (OMMT) nanocomposites were developed to improve bone tissue engineering. These PHB/OMMT materials show enhanced properties, making them suitable for bone regeneration applications.

Keywords:
biomedical technologymontmorillonitenano-claynanoblendnanocompositepolyhydroxy butyratetissue engineering

More Related Videos

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

2.1K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.2K

Related Experiment Videos

Last Updated: Oct 12, 2025

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

3.9K
Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

2.1K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.2K

Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Nanotechnology

Background:

  • Bone-related diseases are increasing globally, necessitating advanced treatments.
  • Polyhydroxybutyrate (PHB)-based nanocomposites offer biocompatibility and biodegradability for tissue engineering.
  • PHB's limitations in bone tissue engineering include inadequate physicochemical and mechanical properties.

Purpose of the Study:

  • To synthesize and characterize PHB-based nanocomposites incorporating organically modified montmorillonite (OMMT) nano-clay.
  • To evaluate the impact of OMMT on the structural, thermal, and morphological properties of PHB.
  • To assess the potential of these novel nanocomposites for bone tissue engineering applications.

Main Methods:

  • Synthesis of PHB/OMMT nanocomposites using a nanoblend and nano-clay filler (modified montmorillonite).
  • Fabrication of nanoblend and nano-clay via the solvent-casting technique.
  • Structural, thermal, and morphological analyses (including FESEM) to characterize the nanocomposites.

Main Results:

  • The basal spacing of the PHB matrix was significantly altered by OMMT loading.
  • PHB/OMMT nanocomposites exhibited enhanced thermal stability and upper working temperature compared to pristine PHB.
  • OMMT facilitated pore formation on the polymer surface, with pore size proportional to OMMT content.

Conclusions:

  • The synthesized PHB/OMMT nanocomposites demonstrate augmented properties over neat PHB.
  • Improved porosity, non-immunogenic nature, and strong biocompatibility suggest suitability for bone tissue engineering.
  • These PHB/OMMT nanocomposites are promising for 3D organ printing, lab-on-a-chip scaffold engineering, and bone regeneration.