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Updated: Oct 12, 2025

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
Published on: July 29, 2022
Alpha-Synuclein and Cognitive Decline in Parkinson Disease
Tian-Sin Fan1, Sam Chi-Hao Liu2, Ruey-Meei Wu2
1Department of Neurology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu City 300, Taiwan.
Abstract:
Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms that occurs during the progression of the disease. The accumulation and spreading of alpha-synuclein pathology from the brainstem to limbic and neocortical structures is correlated with emerging cognitive decline in PD. This review summarizes the genetic and pathophysiologic relationship between alpha-synuclein and cognitive impairment in PD, together with potential areas of biomarker advancement.
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