[Antiproliferative effect of an extract of Aspergillus terreus]

We have studied antiproliferative effect of Aspergillus terreus extract on various cell lines: I-407 normal human cells, L-929 normal murine cells, K-562 erythroleukemic human cells, IAD lymphoblastoid human cells and B 95-8 monkey lymphoblastoid cells. K-562 and lymphoblastoid cells showed higher sensitivity to the extract. Moreover, "a cytostatic dose" of the extract on K-562 cells (12.5 micrograms/ml showed a reduction of 3H-thymidine (but not of 14C-uracil) incorporation, leading us to hypothesize a prevalent action on DNA synthesis.