Related Experiment Video
Updated: Oct 12, 2025
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Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
Published on: September 27, 2012
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Epigenetic Clock and Circadian Rhythms in Stem Cell Aging and Rejuvenation
Ekaterina M Samoilova1, Vladimir V Belopasov2, Evgenia V Ekusheva3
1Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, FMBA of Russia, 115682 Moscow, Russia.
Journal of Personalized Medicine
|November 27, 2021
Summary
Circadian rhythms and epigenetic clocks, marked by DNA methylation, influence cellular aging and stem cell function. Understanding these links offers potential for anti-aging therapies and understanding diseases like cancer.
Area of Science:
- Chronobiology
- Epigenetics
- Cellular senescence
Background:
- Circadian rhythms regulate gene expression, with up to 20% of genes oscillating daily.
- Epigenetic clocks, based on DNA methylation patterns, track cellular age and senescence.
- The interplay between circadian gene expression and epigenetic clocks is crucial for understanding aging and disease.
Purpose of the Study:
- To review the interaction between circadian rhythms and epigenetic clocks.
- To discuss the molecular mechanisms regulating circadian genes and their epigenetic control.
- To explore the role of these processes in stem cell aging, regeneration, and oncogenesis.
Main Methods:
- Literature review of circadian gene regulation and epigenetic mechanisms.
- Analysis of DNA methylation profiles for epigenetic clock determination.
- Discussion of gene functions in circadian rhythms, aging, and cancer.
Main Results:
- Circadian rhythms rely on epigenetic mechanisms like histone modification and DNA methylation.
- Specific genes (e.g., Sirt1, Wee1, c-Myc) are involved in both circadian regulation and aging.
- DNA methylation patterns serve as epigenetic clocks, linking stem cell function, aging, and cancer.
Conclusions:
- Epigenetic clocks and circadian rhythms are interconnected, impacting cellular aging and stem cell fate.
- Modulating epigenetic clocks offers potential therapeutic strategies for anti-aging and disease prevention.
- Understanding these interactions is key to developing novel regenerative and anti-cancer therapies.
Keywords:
CpG-islandsDNA methylationagingcircadian clockepigenetic clockinduced pluripotent stem cellsmethylomereprogrammingsenescenceMore Related Videos
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