Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Prokaryotic Cells01:28

Prokaryotic Cells

42.4K
Prokaryotes are small unicellular organisms that include the domains — Archaea and Bacteria. Bacteria include many common microorganisms, such as Salmonella and E. coli, while the Archaea include extremophiles that live in harsh environments, such as volcanic springs.
Like eukaryotic cells, all prokaryotic cells are surrounded by a plasma membrane, have genetic material in the form of single, circular DNA, a cytoplasm that fills the interior of the cell, and ribosomes that synthesize...
42.4K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.6K
Viral Replication: Lysogenic Cycle01:16

Viral Replication: Lysogenic Cycle

423
The lysogenic cycle is a crucial viral replication strategy that allows bacteriophages to persist within host cells without immediately destroying them. This process is primarily observed in temperate phages, such as bacteriophage lambda (λ), which infects Escherichia coli. The cycle allows the viral genome to persist across bacterial generations while keeping host cells viable.Integration of the Viral GenomeUpon infection, bacteriophage lambda attaches to the bacterial surface and injects...
423
Autophagy01:27

Autophagy

4.8K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.8K
Endospores and Sporulation01:20

Endospores and Sporulation

1.6K
Endospores are specialized, dormant cells primarily formed by Gram-positive bacteria, including Bacillus and Clostridium, enabling survival under extreme environmental conditions. Due to their unique composition and formation process, these structures are highly resistant to physical and chemical insults, such as extreme heat, ultraviolet and ionizing radiation, desiccation, and toxic chemicals. Rare instances of endospore-like structures have also been observed in some Gram-negative bacteria,...
1.6K
Stringent Response in E. coli01:23

Stringent Response in E. coli

77
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
77

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tail-specific protease (Tsp)-mediated envelope remodeling and beta-lactam tolerance in <i>Escherichia coli</i>.

Microbiology spectrum·2026
Same author

UV-B-induced DNA repair mechanisms and their effects on mutagenesis and culturability in <i>Escherichia coli</i>.

mSystems·2026
Same author

Glycerol-Driven Energy and Proteostasis Underpin Antibiotic Tolerance in <i>Escherichia coli</i>.

bioRxiv : the preprint server for biology·2026
Same author

Plasticity, signaling, and metabolic rewiring in melanoma persister cells.

Communications biology·2026
Same author

Beyond metabolic dormancy: metabolic rewiring in bacterial persistence.

Nature communications·2026
Same author

Systematic design of pulse dosing to eradicate persister bacteria: The case of fluoroquinolones.

Computers & chemical engineering·2025
Same journal

Correction: Peptine et al. Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) and Vancomycin-Resistant Enterococci (VRE) in Nosocomial Infections: A Systematic Review of Resistance, Pathogenesis, and Clinical Management. <i>Microorganisms</i> 2026, <i>14</i>, 428.

Microorganisms·2026
Same journal

Torque Teno Virus (TTV) Plasma Load and Immune Reconstitution in People Living with HIV: A Systematic Review.

Microorganisms·2026
Same journal

Optimizing Bacteriophage Screening and Isolation Methods for Microbial Samples Derived from Different Body Sites of Cattle.

Microorganisms·2026
Same journal

Enhanced Biphenyl Degradation by <i>Rhodococcus</i> sp. TG-1 Under Cr(VI) Stress via Modified Biochar Immobilization.

Microorganisms·2026
Same journal

In Vitro Detection of Biologically Active Staphylococcal Enterotoxins Type B and C1 as an Alternative to In Vivo Testing.

Microorganisms·2026
Same journal

Monitoring Hygiene Protocols and Exploring Alternatives to Counteract Resistant Pathogens: A Case Study from Southern Italy on Healthcare-Associated Infection Control.

Microorganisms·2026
See all related articles

Related Experiment Video

Updated: Oct 11, 2025

High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence
07:25

High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence

Published on: February 23, 2021

4.2K

Cellular Self-Digestion and Persistence in Bacteria.

Sayed Golam Mohiuddin1, Sreyashi Ghosh1, Han G Ngo1

  • 1Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77004, USA.

Microorganisms
|November 27, 2021
PubMed
Summary
This summary is machine-generated.

Cellular self-digestion aids bacterial survival during stress by recycling molecules. This process may also offer temporary antibiotic protection, linking it to bacterial persistence mechanisms.

Keywords:
RNA degradationautophagybacterial persistersintracellular degradationlipid degradationprotein degradationself-digestionstationary-phase metabolismviable but non-culturable cells

More Related Videos

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli
12:29

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Published on: March 24, 2023

2.3K
Monitoring Intraspecies Competition in a Bacterial Cell Population by Cocultivation of Fluorescently Labelled Strains
06:45

Monitoring Intraspecies Competition in a Bacterial Cell Population by Cocultivation of Fluorescently Labelled Strains

Published on: January 18, 2014

8.7K

Related Experiment Videos

Last Updated: Oct 11, 2025

High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence
07:25

High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence

Published on: February 23, 2021

4.2K
Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli
12:29

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Published on: March 24, 2023

2.3K
Monitoring Intraspecies Competition in a Bacterial Cell Population by Cocultivation of Fluorescently Labelled Strains
06:45

Monitoring Intraspecies Competition in a Bacterial Cell Population by Cocultivation of Fluorescently Labelled Strains

Published on: January 18, 2014

8.7K

Area of Science:

  • Microbiology
  • Cell Biology
  • Molecular Biology

Background:

  • Cellular self-digestion is an evolutionarily conserved process in prokaryotes.
  • It is triggered by extracellular stress, such as nutrient depletion, leading to intracellular component degradation.
  • This process can impair bacterial growth upon nutrient reintroduction but may offer temporary antibiotic protection.

Purpose of the Study:

  • To review the potential roles of cellular self-digestion in bacterial persistence.
  • To explore the link between self-digestion and antibiotic resistance mechanisms.

Main Methods:

  • This is a review article.
  • It synthesizes existing research on cellular self-digestion and bacterial persistence.
  • Key degradative enzymes like proteases and ribonucleases (RNases) are discussed in relation to these processes.

Main Results:

  • Self-digestion facilitates survival under stress by recycling essential molecules.
  • Self-digestion can lead to temporary antibiotic tolerance.
  • Many bacterial persistence mechanisms are linked to self-digestion, involving degradative enzymes.

Conclusions:

  • Cellular self-digestion plays a significant role in bacterial adaptation to stressful environments.
  • The interplay between self-digestion and degradative enzymes is crucial for bacterial persistence and potential antibiotic tolerance.
  • Further research into self-digestion mechanisms could reveal novel strategies for combating bacterial infections.