Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Towards Sensitization Profiling for Allergy Prevention in Russia: A Systematic Review.

International journal of molecular sciences·2026
Same author

One more opportunity in early-stage cervical cancer: the role of photodynamic therapy in managing positive surgical margins.

Journal of gynecologic oncology·2026
Same author

Tuning Poly(dimethylsiloxane) Hydrophilization and Coating Stability via the Optimization of Polyethylene Glycol Molecular Weight.

Polymers·2025
Same author

Enhanced Light-Matter Interaction in Porous Silicon Microcavities Structurally Optimized Using Theoretical Simulation and Experimental Validation.

Nanomaterials (Basel, Switzerland)·2025
Same author

Major Cat Allergen Fel d 4: Structure and Identification of a Cross-Reactive IgE-Epitope-Containing Area.

Allergy·2025
Same author

Molecular IgE Reactivity Profiling With Micro-Arrayed Allergens Reveals Distinct Interregional Patterns of Sensitization and a Hypoallergenic Region in Türkiye.

Allergy·2025

Related Experiment Video

Updated: Jul 24, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.5K

Designing Functionalized Polyelectrolyte Microcapsules for Cancer Treatment.

Daria Kalenichenko1,2, Galina Nifontova1,2, Alexander Karaulov3

  • 1Laboratoire de Recherche en Nanosciences, LRN-EA4682, Université de Reims Champagne-Ardenne, 51100 Reims, France.

Nanomaterials (Basel, Switzerland)
|November 27, 2021
PubMed
Summary

Researchers developed novel polyelectrolyte microcapsules (MCs) for simultaneous cancer treatment and imaging. These microcapsules effectively deliver doxorubicin (DOX) and quantum dots (QDs), offering a promising platform for targeted cancer therapy and diagnostics.

Keywords:
doxorubicin encapsulationfluorescence imagingoptical encodingpolyelectrolyte microcapsulesquantum dots

More Related Videos

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

15.1K
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

9.0K

Related Experiment Videos

Last Updated: Jul 24, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.5K
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

15.1K
A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

9.0K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cancer Therapeutics

Background:

  • Developing dual-purpose delivery systems for simultaneous cancer imaging and treatment is crucial for advancing oncology.
  • Polyelectrolyte microcapsules (MCs) are a versatile platform for creating multifunctional agents, incorporating drugs, nanoparticles, and fluorescent dyes.

Purpose of the Study:

  • To engineer size-homogenous polyelectrolyte microcapsules (MCs) and microbeads for co-delivery of doxorubicin (DOX) and quantum dots (QDs).
  • To investigate optimal conditions for DOX encapsulation and optical encoding of MCs with QDs for combined therapy and imaging.

Main Methods:

  • Synthesis of core/shell and shell-type polyelectrolyte microcapsules (MCs).
  • Encapsulation of doxorubicin (DOX) and water-soluble quantum dots (QDs) at various stages.
  • Characterization of particle size, DOX and QD encapsulation efficiency, and drug release kinetics.

Main Results:

  • Successfully developed size-homogenous MCs with distinct core/shell and shell structures.
  • Achieved efficient encapsulation of DOX and QDs, enabling dual functionality.
  • Demonstrated modified (prolonged) DOX release under physiological conditions and bright fluorescence for imaging.

Conclusions:

  • The engineered polyelectrolyte MCs offer a promising platform for simultaneous drug delivery and fluorescence imaging in cancer therapy.
  • These microcapsules facilitate targeted delivery of anticancer drugs and provide real-time imaging capabilities.
  • The developed system supports the advancement of theranostic tools for malignant tumor treatment and diagnosis.