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Related Experiment Video

Updated: Oct 11, 2025

Imaging Neutrophils and Monocytes in Mesenteric Veins by Intravital Microscopy on Anaesthetized Mice in Real Time

Imaging Neutrophils and Monocytes in Mesenteric Veins by Intravital Microscopy on Anaesthetized Mice in Real Time

Published on: November 16, 2015

Imaging innate immunity.

Anika Grüneboom¹, Oliver Aust¹, Zülal Cibir²

¹Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V, Dortmund, Germany.

Immunological Reviews

|November 27, 2021

Summary

This summary is machine-generated.

This review highlights how advanced microscopy reveals the crucial roles of innate immune cells, like neutrophils and macrophages, in fighting infections and causing sterile inflammation in disease models.

Keywords:

confocal laser scanning microscopy intravital 2-Photon laser scanning microscopy light-sheet fluorescence microscopy macrophages neutrophils spinning disk confocal microscopy

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Last Updated: Oct 11, 2025

Imaging Neutrophils and Monocytes in Mesenteric Veins by Intravital Microscopy on Anaesthetized Mice in Real Time

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Published on: November 16, 2015

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Non-invasive Imaging of Leukocyte Homing and Migration in vivo

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Published on: December 5, 2010

Area of Science:

Immunology
Cell Biology
Microscopy

Background:

Innate immunity provides the initial defense against pathogens and contributes to sterile inflammation.
Microscopic imaging of immune cells, such as neutrophils, monocytes, and macrophages, has a long history yielding new discoveries.
Intravital microscopy was initially restricted to small invertebrates but has advanced significantly.

Purpose of the Study:

To review recent findings on neutrophil and macrophage biology using advanced microscopy techniques.
To discuss the dual roles of these innate immune cells in infection defense and sterile inflammation.
To explore future directions for enhancing our understanding and diagnostic applications of innate immune cell function.

Main Methods:

Confocal microscopy
Two-photon microscopy
Light-sheet microscopy
In vivo imaging in mammalian disease models

Main Results:

Advanced microscopy provides novel insights into neutrophil and macrophage behavior.
These cells exhibit both protective and detrimental effects in various disease contexts, including tumors and ischemia-reperfusion injury.
The review covers findings from mammalian disease models relevant to human health.

Conclusions:

Microscopy continues to be vital for understanding innate immune cell dynamics.
Neutrophils and macrophages play complex roles in health and disease.
Future research holds potential for improved disease diagnostics based on innate immune cell function.