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Skin microbiome of atopic dermatitis
Li Fang Koh1, Ruo Yan Ong1, John E Common1
1A∗STAR Skin Research Labs (A∗SRL), Singapore, Singapore.
Summary
The skin microbiome
Area of Science:
- Dermatology and Microbiology
Background:
- Atopic dermatitis (AD) is linked to skin microbiome dysbiosis, featuring reduced diversity and increased Staphylococcus aureus.
- Early-life immune responses to microbes and microbial community dynamics significantly impact skin microbiome development.
Purpose of the Study:
- To explore the role of skin microbiota in atopic dermatitis pathogenesis.
- To identify microbial interactions and their impact on host immune responses and skin barrier function.
Main Methods:
- Review of recent studies on skin microbiome composition in AD patients.
- Analysis of microbial interactions, including pathogenic and protective species.
- Investigation of microbial modulation of host cellular responses (keratinocytes, immune cells, adipocytes).
Main Results:
- Dysbiosis, characterized by reduced microbial diversity and S. aureus overgrowth, is a hallmark of AD skin.
- Certain microbes, like Staphylococcal, Roseomonas, and Cutibacterium strains, can inhibit S. aureus and show probiotic potential for AD.
- Skin microbes interact with host cells to influence skin health and barrier function.
Conclusions:
- Understanding skin microbiota bioactives offers new therapeutic avenues for AD.
- Targeting the skin surface microenvironment through biotherapeutics is a promising strategy for AD treatment.
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