Risk Factors for Adverse Maternal Outcomes following Expectantly Managed Preterm Prelabor Rupture of Membranes

Area of Science:

• Obstetrics and Gynecology
• Maternal-Fetal Medicine
• Public Health

Background:

• Preterm prelabor rupture of membranes (PPROM) is a significant obstetric complication.
• Maternal morbidity following PPROM can lead to severe adverse outcomes.
• Characterizing risk factors is crucial for targeted interventions.

Purpose of the Study:

• To determine the incidence of maternal morbidity in patients with PPROM.
• To identify risk factors associated with the development of maternal morbidity after PPROM.
• To inform clinical counseling and public health initiatives.

Main Methods:

• Retrospective case-control study.
• Inclusion of patients with PPROM from 2013-2019 at ≥23 weeks gestational age.
• Statistical analysis including bivariate statistics and regression models to identify risk factors.

Main Results:

• Maternal morbidity occurred in 17.7% of patients with PPROM.
• Severe maternal morbidity was observed in 2.5% of patients.
• Significant risk factors for maternal morbidity included: cesarean delivery, BMI ≥40, private insurance, and tobacco use.

Conclusions:

• Maternal morbidity is a notable complication of PPROM.
• Specific factors like obesity, insurance status, smoking, and delivery method increase morbidity risk.
• Findings support enhanced patient counseling and smoking cessation programs.