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INI1-Intact Sinonasal Carcinoma with Rhabdoid Features.

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This study details a rare sinonasal malignancy, an INI1-intact composite carcinoma, in a patient presenting with nasal obstruction and epistaxis. The findings highlight the importance of accurate pathologic diagnosis for these complex tumors.

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Area of Science:

  • Oncology
  • Pathology
  • Otorhinolaryngology

Background:

  • Sinonasal malignancies often present with advanced disease and diverse histology, contributing to a poor prognosis.
  • Accurate pathologic diagnosis is critical for effective management of sinonasal cancers.

Observation:

  • A 63-year-old male presented with chronic left-sided nasal obstruction and epistaxis.
  • A large nasal cavity mass was observed, extending into the nasopharynx and originating from the maxillary sinus floor with medial wall erosion.

Findings:

  • Pathology revealed an INI1-intact poorly differentiated composite carcinoma with rhabdoid, sarcomatoid, and squamous cell carcinoma components.
  • The carcinoma arose within a background of inverted papilloma, representing a pathologically novel sinonasal neoplasm.

Implications:

  • This case report elucidates the complex features of a rare sinonasal tumor.
  • Improved understanding may enhance future diagnosis and stimulate research into sinonasal malignancies with complex histology.