Related Experiment Video
Updated: Oct 11, 2025

09:08
Sample Preparation for Metabolic Profiling using MALDI Mass Spectrometry Imaging
Published on: December 22, 2020
6.5K
MALDI-MS: Emerging roles in pathology and laboratory medicine
Mark Duncan1, Mari L DeMarco2,3
1Biodesix Inc., Boulder, CO, USA.
Clinical Mass Spectrometry (Del Mar, Calif.)
|November 29, 2021
Abstract:
•MALDI-MS is a valuable analytical tool in pathology and laboratory medicine.•Advantages of MALDI-MS include ease of sample preparation and analysis.•Uses include ID of pathogens, monoclonal proteins, variants and diseased tissue.
Keywords:
CLIP, corticotropin-like intermediate lobe peptideDiagnosticsGenotypingLC-MS/MS, liquid chromatography tandem mass spectrometryMALDI, matrix-assisted laser desorption/ionizationMS, mass spectrometryMSI, mass spectrometry imagingMass spectrometryMatrix-assisted laser desorption/ionizationMedicineProteinTOF, time of flightTissue imagingRelated Concept Videos
MALDI-TOF Mass Spectrometry
5.8K
Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
5.8K
Matrix-Assisted Laser Desorption Ionization (MALDI)
598
Matrix-assisted laser desorption ionization (MALDI) is a powerful analytical technique used in mass spectrometry. It enables the identification and characterization of various biomolecules, including proteins, peptides, nucleic acids, and carbohydrates. MALDI spectrometry is widely employed in biological and medical research, as well as in fields like pharmacology and biochemistry.
The analyte of interest, a biomolecule or a mixture of biomolecules, is mixed with a suitable matrix material. The...
The analyte of interest, a biomolecule or a mixture of biomolecules, is mixed with a suitable matrix material. The...
598
Three-Dimensional Microscopy in Microbiology
433
Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
433

