Related Experiment Video
Updated: Oct 11, 2025

Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST
Published on: November 2, 2018
New Algorithm by Maximizing Mutual Information for Correction of Frequency Drifts Arising from One-Dimensional NMR
1Department of Applied Chemistry, Faculty of Science and Technology, Meijo University, 1-501 Shiogamaguchi, Tenpaku-ku, Nagoya 468-8502, Aichi, Japan.
Abstract:
Benchtop nuclear magnetic resonance (NMR) instruments are getting popular these days. However, the obtained spectra sometimes suffer from significant frequency drifts, which cause difficulty in accumulating the raw data. In this paper, a new algorithm for correction of frequency drifts is proposed, which operates by maximizing mutual information between the obtained spectroscopic data. The algorithm worked well for both 1H and 19F NMR spectroscopic data, even in the case of very noisy ones. In comparison with the previously reported algorithms, the present algorithm has an advantage that NMR spectra complicated by signal overlapping and spin coupling can be handled without difficulty. This makes the present algorithm particularly advantageous for application of benchtop NMR spectrometers in organic chemistry.
Related Concept Videos
NMR Spectrometers: Resolution and Error Correction
¹H NMR: Interpreting Distorted and Overlapping Signals
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...
2D NMR: Overview of Homonuclear Correlation Techniques
COSY90 is the standard two-dimensional (2D) COSY experiment that...
Interpreting ¹H NMR Signal Splitting: The (n + 1) Rule
NMR Spectrometers: Overview
¹H NMR Signal Multiplicity: Splitting Patterns

