Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.3K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.3K
Tumor Immunotherapy01:27

Tumor Immunotherapy

725
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
725
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

1.3K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
1.3K
Development of Immunocompetence01:22

Development of Immunocompetence

503
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
503

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Polyunsaturated Fatty Acids (PUFAs) in the Primary Prevention of Allergic Diseases in Children: A Position Paper of the SIAIP Primary and Secondary Prevention of Allergic Diseases and Nutraceuticals Committees.

Nutrients·2026
Same author

Micronutrient status and growth outcomes in children with cow's milk allergy: beyond elimination diets.

Frontiers in nutrition·2026
Same author

Evidence-Based Clinical Recommendations for the Appropriate Use of Diagnostic Tests in Pediatric Allergology: Focus on Asthma, Rhinoconjunctivitis, and Keratoconjunctivitis Vernal.

Journal of clinical medicine·2026
Same author

Emerging Paediatric Uses of Dupilumab Beyond Approvals.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Hypertransaminasemia Is a Marker of Severity in Children Hospitalized for Influenza.

Influenza and other respiratory viruses·2026
Same author

Biological drugs for the treatment of children with atopic dermatitis.

Expert opinion on biological therapy·2026

Related Experiment Video

Updated: Oct 11, 2025

Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
08:49

Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype

Published on: March 18, 2020

11.2K

Tailored therapies for primary immunodeficiencies.

Bianca Cinicola1, Federica Pulvirenti2, Giulia Brindisi3

  • 1Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy; Department of Experimental Medicine Sapienza University of Rome, Rome, Italy. biancacinicola@gmail.com.

Acta Bio-Medica : Atenei Parmensis
|November 29, 2021
PubMed
Summary

Precision medicine advances offer new hope for primary immunodeficiency disorders (PIDs). Tailored treatments, including gene therapy, are improving outcomes and quality of life for patients with these rare immune system disorders.

More Related Videos

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

16.9K
High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
11:31

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

8.1K

Related Experiment Videos

Last Updated: Oct 11, 2025

Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
08:49

Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype

Published on: March 18, 2020

11.2K
Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

16.9K
High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
11:31

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

8.1K

Area of Science:

  • Immunology
  • Genetics
  • Precision Medicine

Background:

  • Primary immunodeficiency disorders (PIDs) are rare, inherited, monogenic conditions affecting the immune system.
  • Over 420 PIDs have been identified, increasing infection risk, immune dysregulation, and malignancies.
  • High-throughput sequencing has elucidated molecular pathways and identified targets for precision treatment.

Purpose of the Study:

  • To review recent advancements in tailored treatments for primary immunodeficiency disorders.
  • To highlight the impact of precision medicine on managing PIDs.

Main Methods:

  • Review of recent findings on targeted therapies for PIDs.
  • Analysis of advancements in immunoglobulin replacement and gene therapy.

Main Results:

  • Targeted therapies effectively manage immune dysregulation and autoimmunity in PIDs, with fewer side effects than conventional treatments.
  • Evolved immunoglobulin replacement therapies and gene therapy offer individualized strategies for improved infection control and quality of life.
  • Gene therapy corrects immunological defects, reducing complications associated with hematopoietic stem cell transplantation.

Conclusions:

  • Tailored treatments represent a significant advancement in managing primary immunodeficiency disorders.
  • Precision medicine approaches are transforming the clinical course and improving patient outcomes for PIDs.
  • Future directions focus on further refining individualized strategies for PID management.