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Multifunctional Polymeric Nanogels for Biomedical Applications.

Tisana Kaewruethai^1,2, Chavee Laomeephol^1,3, Yue Pan⁴

¹Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phayathai Road, Bangkok 10330, Thailand.

Gels (Basel, Switzerland)

|November 29, 2021

Summary

This summary is machine-generated.

Nanogels, water-rich nanoparticles, offer enhanced colloidal stability and tunable structures for advanced drug delivery and theranostic applications. Their core-shell designs, functionalized with polymers or metals, enable stimuli-responsive behavior for targeted biomedical uses.

Keywords:

core-shell nanogels functionalized polymer polymeric nanogels stimuli-responsive

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Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Nanoparticles are increasingly researched for drug delivery, diagnostics, and theranostics.
Nanogels, water-rich nanoparticles, exhibit desirable properties like colloidal stability and tunable structures.
Their core-shell architecture facilitates the development of multifunctional nanosystems.

Purpose of the Study:

To review diverse core-shell nanogel designs.
To highlight fabrication methods and stimuli-responsive properties of nanogels.
To present biomedical applications showcasing nanogel versatility.

Main Methods:

Review of existing literature on nanogel fabrication and characterization.
Analysis of functionalization strategies using polymers and metals.
Examination of nanogel responsiveness to stimuli (temperature, pH, reductive environments, radiation).

Main Results:

Nanogels can be engineered with enhanced features like amphiphilicity, biocompatibility, and stimuli-responsiveness.
Functionalization improves specificity, stability, and tracking capabilities.
Demonstrated responsiveness to various external stimuli.

Conclusions:

Core-shell nanogels represent a versatile platform for advanced biomedical applications.
Functionalized nanogels offer tailored properties for drug delivery, diagnostics, and theranostics.
Further research into nanogel design and application is warranted.