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Updated: Oct 11, 2025
Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
Published on: December 13, 2024
Evaluation of aloins, pH and moisture in aloe leaf gel-based personal care products
Gereziher Sibhat1,2, Getu Kahsay2, Ann Van Schepdael1
1Pharmaceutical Analysis, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
Objective:
Some easily applicable analytical methods were explored to evaluate the quality of personal care products containing aloe leaf gel. Aloins should be absent in these products in view of their side effects. To check this, liquid chromatography (LC) was applied.
Methods:
The LC method used a C18 monolithic column combined with gradient elution and ultraviolet (UV) detection. The mobile phase consisted of a mixture of 0.1% formic acid in water (A) and 0.1% formic acid in acetonitrile (B). The method was validated with respect to specificity, linearity, precision and accuracy. Next, it was practically applied for the analysis of commercial samples. In addition, the pH and moisture content were determined.
Results:
The LC results indicated that aloins were detected in 25% of the analysed commercial samples. Further, it turned out that 42% of the test samples were found to be in the basic pH range and 33% of them contained excessive moisture.
Conclusion:
Proper quality control and adequate labelling of aloe leaf gel-based cosmetics are mandatory to avoid side effects.
