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Updated: Oct 11, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Rhodium(III)-Catalyzed Cascade Reactions of Imines/Imidates with 4-Hydroxy-2-alkynoates to Synthesize Regioselective
Anil Kumar1, Vinayak Hanchate1, Kandikere Ramaiah Prabhu1
1Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, Karnataka, India.
Abstract:
A regioselective synthesis of furanone-fused isoquinoline heterocycles is developed in a single step using a Rh(III) catalyst. In this reaction, a cascade C-H activation, regioselective annulation, and lactonization occur in one pot. A wide range of alkynoates was examined, which showed good regioselectivity. The regioselectivity was guided by steric bulk at the C4 position of the 4-hydroxy-2-alkynoates. The synthetic utility was exemplified, and the model reaction was scaled up to a 1 g scale.
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