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Related Experiment Video

Updated: Oct 11, 2025

Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention

Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention

Published on: October 6, 2023

Local acetate inhibits brown adipose tissue function.

Wenfei Sun¹, Hua Dong², Christian Wolfrum¹

¹Institute of Food, Nutrition, and Health, Eidgenössiche Technische Hochschule Zurich, CH 8603 Zurich, Switzerland wenfei-sun@ethz.ch christian-wolfrum@ethz.ch.

Proceedings of the National Academy of Sciences of the United States of America

|November 30, 2021

Summary

This summary is machine-generated.

Local acetate directly inhibits brown fat thermogenesis, reducing energy expenditure. This study reveals acetate

Keywords:

RNA-seq acetate brown adipose tissue obesity

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Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

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Published on: February 18, 2015

Area of Science:

Metabolism
Obesity Research
Adipose Tissue Biology

Background:

Brown adipose tissue (BAT) is a key target for combating obesity.
Paracrine regulation within BAT remains poorly understood.

Purpose of the Study:

To investigate the role of local acetate in regulating brown adipose tissue function.
To elucidate the mechanisms by which acetate affects BAT thermogenesis and energy expenditure.

Main Methods:

Direct administration of acetate within brown adipose tissue.
Measurement of thermogenesis and systemic energy expenditure.
Transcriptomic analysis to identify affected gene pathways.

Main Results:

Local acetate administration directly inhibits brown fat thermogenesis.
Acetate's effects occur without altering circulating acetate levels.
Modulating local acetate blunts BAT function and decreases systemic energy expenditure.
Transcriptomic analysis revealed down-regulation of genes in the tricarboxylic acid cycle and brown adipocyte formation.

Conclusions:

Local acetate acts as an endogenous inhibitor of brown adipose tissue thermogenesis.
Acetate's inhibitory effect on BAT contributes to decreased systemic energy expenditure.
Findings highlight a novel paracrine regulatory mechanism in brown adipose tissue.