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Related Experiment Video

Updated: Oct 11, 2025

Studying Inherited Immunity in a Caenorhabditis elegans Model of Microsporidia Infection

Studying Inherited Immunity in a Caenorhabditis elegans Model of Microsporidia Infection

Published on: April 6, 2022

Helminths make themselves at home.

Elia D Tait Wojno¹

¹Department of Immunology, University of Washington, Seattle, WA.

The Journal of Experimental Medicine

|November 30, 2021

Summary

Parasitic helminths, like Heligmosomoides polygyrus, release products that suppress the small intestine's protective epithelial response. This reveals how helminths directly alter host tissues during infection.

Area of Science:

Immunology
Parasitology
Gastroenterology

Background:

Helminth infections are common globally.
Understanding host-parasite interactions is crucial for developing treatments.
The small intestine's epithelial response plays a key role in immunity.

Purpose of the Study:

To investigate how Heligmosomoides polygyrus excretory/secretory products affect the host's small intestinal epithelial response.
To elucidate the mechanisms of helminth-induced modulation of host tissues.

Main Methods:

Analysis of excretory/secretory products from Heligmosomoides polygyrus.
Assessment of the impact on small intestinal epithelial cells.
Investigation of host-parasite interactions in vivo.

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Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni

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Published on: April 6, 2022

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Published on: May 24, 2011

Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni

Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni

Published on: January 14, 2018

Main Results:

Excretory/secretory products from Heligmosomoides polygyrus were found to suppress the host-protective small intestinal epithelial response.
Helminths were shown to directly modulate the host's intestinal tissue.
This modulation impacts the host-protective mechanisms.

Conclusions:

Helminths possess mechanisms to directly interfere with host tissue function.
These findings provide new insights into the complex host-parasite relationship.
Targeting these suppressive mechanisms could offer therapeutic strategies.