Related Experiment Video
Updated: Oct 11, 2025

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
Published on: April 25, 2022
[Interrelation of microRNAs and transposons in aging and carcinogenesis.]
1Bashkir State Medical University, 3 Lenin str., Ufa 450008, Russian Federation,
Abstract:
Dysregulation of transposable elements plays a key role in human carcinogenesis. Physiological aging in humans is also caused by deregulation of transposons. Moreover, aging is associated with the development of cancer. We presented the results of an analysis of data on the presence of common epigenetic changes during aging and carcinogenesis, associated with changes in the expression of microRNAs derived from transposons. We found that aging is characterized by changes in the expression of 21 specific transposon-derived microRNAs associated with the development of malignant neoplasms. Before us, evidence similar to ours on the relationship between the mechanisms of aging and carcinogenesis at the epigenetic level has not been presented. We hypothesized that one of the key mechanisms of aging is an imbalance in the programmed activation of mobile genetic elements, which is reflected in changes in the body's epigenetic regulation and leads to an increased risk of cancer. Since miRNA precursors can be translated with the formation of functional molecules, peptides used in gerontology can be considered as potential anticancer drugs.
Related Concept Videos
MicroRNAs
Non-LTR Retrotransposons
piRNA - Piwi-interacting RNAs
Overview of Transposition and Recombination
Transposons
DNA-only Transposons
The donor site from where the transposon is excised is either degraded or...

