Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chirality

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same authorSame journal

Correlative Multimodal Framework Reveals Supramolecular Chirality Loss Preceding Fibrillar Rarefaction in Dermal Collagen.

ACS nano·2026

Same author

Role of structural isomerism in the properties of imine-based organic hole-transporting materials.

Physical chemistry chemical physics : PCCP·2026

Same author

Interaction of Polymer of Intrinsic Microporosity PIM‑1 with Explosive Analytes at the Molecular Level: Combined Experiment and Computational Modeling.

The journal of physical chemistry. C, Nanomaterials and interfaces·2026

Same author

Metasurface analogues of molecular diastereomers from hierarchical multiscale chiral interactions with biomolecules.

Nature communications·2026

Same author

Gallium Oxide-Based Photodetectors for Water Quality Monitoring.

ACS applied optical materials·2026

Same author

Optical write-erase chemical memory state in plasmonic nanoarrays.

Chemical science·2025

Search research articles

Related Experiment Video

Updated: Oct 11, 2025

Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays

Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays

Published on: June 28, 2024

Chiral Quantum Metamaterial for Hypersensitive Biomolecule Detection.

Maryam Hajji¹, Michele Cariello¹, Cameron Gilroy¹

¹School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.

|November 30, 2021

Summary

Chiral quantum metamaterials enable highly sensitive detection of individual biomolecules. This breakthrough overcomes limitations in chiral molecule analysis, paving the way for next-generation biodetection technologies.

Keywords:

chiral plasmonics quantum dots quantum metamaterials superchirality

More Related Videos

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

Related Experiment Videos

Last Updated: Oct 11, 2025

Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays

Author Spotlight: High-Quality Quantum Dot Nanobeads for Sensitive Fluorescent Lateral Flow Immunoassays

Published on: June 28, 2024

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

Area of Science:

Optics and Photonics
Materials Science
Biophysics

Background:

Chiral molecules are crucial in biology and pharmaceuticals.
Current detection methods for chiral molecules are limited by weak light interactions, falling short of single-molecule sensitivity.
Existing techniques are significantly less sensitive than single-molecule detection levels.

Purpose of the Study:

To develop a novel phenomenon for highly sensitive chiral molecule detection.
To overcome the intrinsic sensitivity limits of current chiral analysis methods.
To demonstrate a new approach for biodetection using chiral quantum metamaterials.

Main Methods:

Utilizing chiral quantum metamaterials (CQMs) integrated with semiconductor quantum dots (QDs) in a chiral nanocavity.
Observing the perturbation of QD emission upon introduction of individual biomolecules (antibodies).
Attributing the effect to local changes in the optical density of states within the CQM.

Main Results:

Demonstrated a phenomenon enabling detection of as few as six antibody molecules per nanocavity.
Achieved sensitivity exceeding current chiral spectroscopic methods by at least six orders of magnitude.
Observed significant perturbation of quantum emitter emission due to biomolecule interaction with the CQM.

Conclusions:

Chiral quantum metamaterials offer a pathway to ultra-sensitive biodetection.
The reported phenomenon is responsive to local optical density changes, invisible to classical methods.
This work enables next-generation technologies for rapid, hypersensitive nanometrology and biodetection.