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Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Kidney Transplant III: Nursing Management01:16

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Imaging Studies VII: Vascular Imaging01:19

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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Renal Failure: Dose Adjustments01:11

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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
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Acute Kidney Injury V: Interprofessional Care01:20

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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Nephrotoxicity after radionuclide therapies.

Ashwin Singh Parihar1, Sejal Chopra1, Vikas Prasad2

  • 1Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

Translational Oncology
|November 30, 2021
PubMed
Summary

Radioligand therapies offer precise cancer treatment but can cause kidney damage. This review explores risks, mechanisms, and management of radionuclide therapy-induced nephrotoxicity.

Keywords:
177Lu90YAcute kidney injuryCKDChronicDOTATATEDOTATOCPRRTPSMARLTRadioimmunotherapyRenal toxicityTheranostics

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Area of Science:

  • Oncology
  • Nephrology
  • Radiology

Background:

  • Radioligand therapies provide targeted cancer treatment with a good efficacy-to-toxicity ratio.
  • Kidneys demonstrate high tolerance to radiation, but nephron loss leads to irreversible function decline.
  • Understanding radiation nephropathy evolved from external beam radiation to radionuclide therapies.

Purpose of the Study:

  • To review radionuclide therapies linked to nephrotoxicity.
  • To discuss factors and mechanisms contributing to renal injury.
  • To outline current and potential strategies for managing radiation-induced nephropathy.

Main Methods:

  • Literature review of radionuclide therapies and associated renal toxicity.
  • Analysis of factors and mechanisms underlying radiation-induced nephropathy.
  • Synthesis of current and emerging methods for nephrotoxicity prevention and management.

Main Results:

  • Radioligand therapies carry a risk of nephrotoxicity.
  • Nephron loss is irreversible, emphasizing the need for renal protection.
  • Evidence is growing on risk factors and mechanisms of renal injury from these therapies.

Conclusions:

  • Effective management of nephrotoxicity is crucial for safe radioligand therapy.
  • Further research into prevention and early identification of renal injury is warranted.
  • Protecting the fixed number of nephrons is key to preserving renal function during cancer treatment.