Charting a global research strategy for progressive MS-An international progressive MS Alliance proposal

Area of Science:

• Neurology
• Immunology
• Clinical Research

Background:

• Progressive multiple sclerosis (MS) affects over 1 million globally, with recent drug approvals offering new therapeutic avenues.
• The term 'active' secondary progressive MS introduces complexity in disease description and clinical management.
• Existing neuroprotective agent trials show mixed results, necessitating refined research approaches.

Purpose of the Study:

• To review recent advancements in progressive MS research.
• To highlight existing knowledge gaps in progressive MS.
• To propose a global research strategy for progressive MS on behalf of the International Progressive MS Alliance.

Main Methods:

• Conducted literature searches in PubMed from 2015 to May 2021 using key terms like "progressive multiple sclerosis".
• Synthesized findings and developed proposed strategies through collaborative meetings of the International Progressive MS Alliance Scientific Steering Committee.

Main Results:

• Accelerating progress requires deeper understanding of disease mechanisms and identification of therapeutic targets.
• Biomarker discovery, validation, and improved clinical trial designs are crucial for advancing treatment.
• Symptomatic and rehabilitative interventions show promise in addressing daily challenges faced by progressive MS patients.

Conclusions:

• A unified global research strategy is essential to manage challenges and capitalize on opportunities in progressive MS.
• Implementing this strategy will improve the quality of life for individuals with progressive MS.
• Continued research and collaboration are key to overcoming the complexities of progressive MS.